FOXO4-DRI 10MG

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FOXO4-DRI 10MG
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FOXO4-DRI | 10mg | Forkhead Box O4 D-Retro Inverso Peptide

For In Vitro Research Use Only — Not for Human or Veterinary Use

Description:
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a synthetic D-retro-inverso peptide antagonist derived from the FOXO4 transcription factor, designed to block the interaction between FOXO4 and p53. This cell-penetrating peptide selectively induces apoptosis in senescent cells by disrupting FOXO4-p53 binding, leading to p53 nuclear exclusion and mitochondrial translocation in dysfunctional cells while sparing healthy ones. It is widely studied for its senolytic properties, potential to restore tissue homeostasis, alleviate age-related dysfunctions, and model anti-aging mechanisms in research. Provided in a 10mg lyophilized format, FOXO4-DRI is intended strictly for advanced laboratory-based in vitro applications.

Specifications:

  • Unit Size: 10mg (lyophilized powder, single vial)

  • Molecular Weight: ~5358.05 Da

  • Molecular Structure: C₂₂₈H₃₈₈N₈₆O₆₄ 

  • Form: Lyophilized powder

  • Storage: Store lyophilized peptide at 2°C–8°C in a dry, dark environment. After reconstitution, keep refrigerated between 2°C–8°C

Application Context:
CJC-1295 w/ DAC is researched for its potential influence on:

  • Selective apoptosis of senescent cells and senolytic activity

  • Disruption of FOXO4-p53 interactions and p53-mediated signaling

  • Restoration of tissue homeostasis, anti-aging models, and age-related disease mechanisms

  • In vitro studies of cellular senescence, apoptosis pathways, and protein-protein interactions

Intended Use:
This product is intended solely for in vitro research use. It is not approved for use in humans or animals and may not be used in food, drugs, diagnostics, or cosmetics.